Manual War World: Discovery

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This proposed Research Topic aims to delineate and conceptualise pharmaceutical innovation within the twentieth century, with an emphasis on the post-World War II era, and to highlight its roots and pathways throughout that period. From the systematic assessment of botanicals and vital stains to the era of structural biology and computational modelling, authors are invited to contribute to the analysis of the historical and scientific details that have shaped pharmaceutical innovation.

We propose the investigation of a variety of paradigm shifting factors, including the development and acceptance of innovative ideas; the impact of contemporary discoveries, theoretical advances and technological developments; the influence of individual scientists; the significance of specific pioneering labs; and the varied and variable roles of industry, funding bodies, regulators and markets.

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Keywords : pharmaceutical innovation, drug discovery, biopharmaceuticals, history, twentieth century, World War II. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review. With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area!

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Mercantile interests, crusading and missionary zeal, and scientific curiosity were intermingled as the motives for this epic achievement. Similar hopes inspired Spanish exploitation of the discovery by Christopher Columbus of the Caribbean outposts of the American continent in The Treaties of Tordesillas and Saragossa in and defined the limits of westward Spanish exploration and the eastern ventures of Portugal.

The two states acting as the vanguard of the expansion of Europe had thus divided the newly discovered sea lanes of the world between them. The seizure of Peru by Francisco Pizarro and the enforcement of Portuguese claims to Brazil completed the major steps in the Iberian occupation of the continent.

By the middle of the century, the age of the conquistadores was replaced by an era of colonization, based both on the procurement of precious metal by Indian labour and on pastoral and plantation economies using imported African slaves. The influx of bullion into Europe became significant in the late s, and from about it began to produce a profound effect upon the economy of the Old World.

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History of Europe.